Maternal Embryonic Leucine Zipper Kinase (MELK) (N-Term) Peptide
MELK
适用: 人, 小鼠
宿主: 合成
BP, WB
Quick Overview for Maternal Embryonic Leucine Zipper Kinase (MELK) (N-Term) Peptide (ABIN2184957)
抗原
MELK
(Maternal Embryonic Leucine Zipper Kinase (MELK))
宿主
人, 小鼠
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- GFAKVKLACH VLTGEMVAIK IMDKNALGSD LPRVKTEIDA LKSLRHQHIC
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产品特性
- This is a synthetic peptide designed for use in combination with anti-Melk Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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Maternal Embryonic Leucine Zipper Kinase (MELK) peptide
MELK 适用: 人, 小鼠, Cow, 犬 宿主: 合成 BP, Imm
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeat freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
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背景
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Melk is a Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Melk Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. It Plays a key role in cell proliferation. It is required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. It's also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus and may also play a role in primitive hematopoiesis.
Alias Symbols: AI327312, MPK38, mKIAA0175
Protein Size: 643 -
分子量
- 70 kDa
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基因ID
- 17279
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NCBI登录号
- NM_010790, NP_034920
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UniProt
- Q61846
抗原
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